3FJN

The crystal structure of 17-alpha hydroxysteroid dehydrogenase Y224D mutant.

3FJN の概要

• エントリーDOI: 10.2210/pdb3fjn/pdb
• 分子名称: Aldo-keto reductase family 1 member C21, ACETATE ION (3 entities in total)
• 機能のキーワード: aldo-keto reductase, 17-alpha-hydroxysteroid dehydrogenase, cytoplasm, lipid metabolism, nadp, oxidoreductase, phosphoprotein, steroid metabolism
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm (By similarity): Q91WR5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73989.16

構造登録者

Dhagat, U.,El-Kabbani, O. (登録日: 2008-12-14, 公開日: 2009-11-24, 最終更新日: 2023-11-01)

• 主引用文献: Dhagat, U.,Endo, S.,Mamiya, H.,Hara, A.,El-Kabbani, O.; Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme; Acta Crystallogr.,Sect.D, 66:198-204, 2010; PubMed: 20124700; DOI: 10.1107/S0907444909051464

実験手法

X-RAY DIFFRACTION (2.3 Å)