3FIQ

Odorant Binding Protein OBP1

3FIQ の概要

• エントリーDOI: 10.2210/pdb3fiq/pdb
• 分子名称: Odorant-binding protein 1F, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: lipocalin, oderant-binding protein, transport protein
• 由来する生物種: Rattus norvegicus (rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36492.25

構造登録者

White, S.A. (登録日: 2008-12-12, 公開日: 2009-05-19, 最終更新日: 2024-11-13)

主引用文献

White, S.A.,Briand, L.,Scott, D.J.,Borysik, A.J.
Structure of rat odorant-binding protein OBP1 at 1.6 A resolution
Acta Crystallogr.,Sect.D, 65:403-410, 2009

PubMed Abstract: The nasal mucosa is a specialist interfacial region sandwiched between the olfactory system and the gaseous chemical milieu. In mammals and insects, this region is rich in odorant-binding proteins that are thought to aid olfaction by assisting mass transfer of the many different organoleptic compounds that make up the olfactory landscape. However, in mammals at least, our grasp on the exact function of odorant-binding proteins is tentative and better insight into the role of these proteins is warranted, not least because of their apparent significance in the olfactory systems of insects. Here, the crystal structure of rat odorant-binding protein 1 is reported at 1.6 A resolution. This protein is one of the best-characterized mammalian odorant-binding proteins and only the third such protein structure to be solved at high resolution. The protein was crystallized in the holo form and contains an unidentifiable ligand that is probably an artefact from the Pichia pastoris expression system. Comparisons are made between this structure and a modelled OBP1 structure produced using the crystal structure of aphrodisin as a template. Comparisons are also made between OBP1 and the other two rat OBP subtypes, for which crystallographic data are unavailable. Interestingly, we also show that OBP1 is monomeric, which is in contrast to its previous assignment.

PubMed: 19390145
DOI: 10.1107/S090744490900420X

実験手法

X-RAY DIFFRACTION (1.599 Å)