3FI4

P38 kinase crystal structure in complex with RO4499

3FI4 の概要

• エントリーDOI: 10.2210/pdb3fi4/pdb
• 分子名称: Mitogen-activated protein kinase 14, (2S)-1-{[3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}propan-2-ol (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43152.53

構造登録者

Kuglstatter, A.,Knapp, M.,Dunten, P. (登録日: 2008-12-10, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Arora, N.,Williams, C.,Delano, W.,Will, D.,Kuglstatter, A.; Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)