Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid

Replaces:  2PA9

Summary for 3FHB

DescriptorPoly [ADP-ribose] polymerase 3, 3-AMINOBENZOIC ACID (3 entities in total)
Functional Keywordstransferase, enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, alternative splicing, glycosyltransferase, nad, nucleus
Biological sourceHomo sapiens
Cellular locationNucleus Q9Y6F1
Total number of polymer chains1
Total molecular weight39889.21
Primary citation
Lehtio, L.,Jemth, A.S.,Collins, R.,Loseva, O.,Johansson, A.,Markova, N.,Hammarstrom, M.,Flores, A.,Holmberg-Schiavone, L.,Weigelt, J.,Helleday, T.,Schuler, H.,Karlberg, T.
Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
J.Med.Chem., 52:3108-3111, 2009
PubMed: 19354255 (PDB entries with the same primary citation)
DOI: 10.1021/jm900052j
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256603.0%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution