3FFN
Crystal structure of calcium-free human gelsolin
Summary for 3FFN
Entry DOI | 10.2210/pdb3ffn/pdb |
Related | 1D0N 1H1V 1P8X 1P8Z 1RGI 2FGH |
Descriptor | Gelsolin (2 entities in total) |
Functional Keywords | gelsolin, actin, ca-dependent, actin capping, actin-binding, alternative initiation, amyloid, amyloidosis, calcium, cytoplasm, cytoskeleton, disease mutation, disulfide bond, phosphoprotein, polymorphism, secreted, actin binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396 |
Total number of polymer chains | 2 |
Total formula weight | 171596.80 |
Authors | Chumnarnsilpa, S.,Robinson, R.C.,Burtnick, L.D. (deposition date: 2008-12-04, release date: 2009-10-06, Last modification date: 2024-02-21) |
Primary citation | Nag, S.,Ma, Q.,Wang, H.,Chumnarnsilpa, S.,Lee, W.L.,Larsson, M.,Kannan, B.,Hernandez-Valladares, M.,Burtnick, L.D.,Robinson, R.C. Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin. Proc.Natl.Acad.Sci.USA, 106:13713-13718, 2009 Cited by PubMed: 19666512DOI: 10.1073/pnas.0812374106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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