3FFN

Crystal structure of calcium-free human gelsolin

Summary for 3FFN

Entry DOI	10.2210/pdb3ffn/pdb
Related	1D0N 1H1V 1P8X 1P8Z 1RGI 2FGH
Descriptor	Gelsolin (2 entities in total)
Functional Keywords	gelsolin, actin, ca-dependent, actin capping, actin-binding, alternative initiation, amyloid, amyloidosis, calcium, cytoplasm, cytoskeleton, disease mutation, disulfide bond, phosphoprotein, polymorphism, secreted, actin binding protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396
Total number of polymer chains	2
Total formula weight	171596.80
Authors	Chumnarnsilpa, S.,Robinson, R.C.,Burtnick, L.D. (deposition date: 2008-12-04, release date: 2009-10-06, Last modification date: 2024-02-21)
Primary citation	Nag, S.,Ma, Q.,Wang, H.,Chumnarnsilpa, S.,Lee, W.L.,Larsson, M.,Kannan, B.,Hernandez-Valladares, M.,Burtnick, L.D.,Robinson, R.C. Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin. Proc.Natl.Acad.Sci.USA, 106:13713-13718, 2009 Cited by PubMed: 19666512 DOI: 10.1073/pnas.0812374106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation