3FEG

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

Summary for 3FEG

Entry DOI	10.2210/pdb3feg/pdb
Descriptor	Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, SULFATE ION, ... (8 entities in total)
Functional Keywords	non-protein kinase, choline kinase, structural genomics consortium, sgc, hemicholinium-3, phosphorylation, kinase, phosphoprotein, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45391.92
Authors	Hong, B.S.,Tempel, W.,Rabeh, W.M.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.W.,Structural Genomics Consortium (SGC) (deposition date: 2008-11-29, release date: 2008-12-23, Last modification date: 2023-09-06)
Primary citation	Hong, B.S.,Allali-Hassani, A.,Tempel, W.,Finerty, P.J.,Mackenzie, F.,Dimov, S.,Vedadi, M.,Park, H.W. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J.Biol.Chem., 285:16330-16340, 2010 Cited by PubMed: 20299452 DOI: 10.1074/jbc.M109.039024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.302 Å)

Structure validation