3FED

The high resolution structure of human glutamate carboxypeptidase III (GCPIII/NAALADase II) in complex with a transition state analog of Glu-Glu

Summary for 3FED

Entry DOI	10.2210/pdb3fed/pdb
Related	3FEC 3FEE 3FF3
Descriptor	Glutamate carboxypeptidase III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	metallopeptidase, bimetallic active site, n-glycosylation, calcium cation, chloride anion, zinc ions, carboxypeptidase, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	81546.18
Authors	Lubkowski, J.,Barinka, C.,Hlouchova, K. (deposition date: 2008-11-28, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Hlouchova, K.,Barinka, C.,Konvalinka, J.,Lubkowski, J. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III Febs J., 276:4448-4462, 2009 Cited by PubMed: 19678840 DOI: 10.1111/j.1742-4658.2009.07152.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation