3FCK

Complex of UNG2 and a fragment-based design inhibitor

3FCK の概要

• エントリーDOI: 10.2210/pdb3fck/pdb
• 関連するPDBエントリー: 3FCF 3FCI 3FCL
• 分子名称: Uracil-DNA glycosylase, 3-({[3-({[(1E)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid (3 entities in total)
• 機能のキーワード: dna repair, uracil, uracil dna glycosylase, alternative splicing, disease mutation, dna damage, glycosidase, host-virus interaction, hydrolase, mitochondrion, nucleus, phosphoprotein, transit peptide
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Mitochondrion. Isoform 2: Nucleus: P13051
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25890.47

構造登録者

Bianchet, M.A.,Chung, S.,Parker, J.B.,Amzel, L.M.,Stivers, J.T. (登録日: 2008-11-21, 公開日: 2009-04-28, 最終更新日: 2023-12-27)

• 主引用文献: Chung, S.,Parker, J.B.,Bianchet, M.,Amzel, L.M.,Stivers, J.T.; Impact of linker strain and flexibility in the design of a fragment-based inhibitor; Nat.Chem.Biol., 5:407-413, 2009; PubMed: 19396178; DOI: 10.1038/nchembio.163

実験手法

X-RAY DIFFRACTION (1.64 Å)