3FC2

PLK1 in complex with BI6727

3FC2 の概要

• エントリーDOI: 10.2210/pdb3fc2/pdb
• 分子名称: Serine/threonine-protein kinase PLK1, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, 1,2-ETHANEDIOL, ... (8 entities in total)
• 機能のキーワード: protein kinase, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P53350
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38883.58

構造登録者

Bader, G. (登録日: 2008-11-21, 公開日: 2009-05-12, 最終更新日: 2023-12-27)

• 主引用文献: Rudolph, D.,Steegmaier, M.,Hoffmann, M.,Grauert, M.,Baum, A.,Quant, J.,Haslinger, C.,Garin-Chesa, P.,Adolf, G.R.; BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity.; Clin.Cancer Res., 15:3094-3102, 2009; PubMed: 19383823; DOI: 10.1158/1078-0432.CCR-08-2445

実験手法

X-RAY DIFFRACTION (2.45 Å)