3FA6

Crystal structure of the R132K:Y134F:R111L:L121D:T54V mutant of cellular retinoic acid-binding protein II complexed with C15-aldehyde (a retinal analog) at 1.54 angstrom resolution

Summary for 3FA6

Related3CR6 3F8A 3F9D 3FA7 3FA8 3FA9
DescriptorCellular retinoic acid-binding protein 2, 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene (3 entities in total)
Functional Keywordscrabpii, retinal, protonated schiff base, psb, c15-aldehyde, retinoic acid, retinoid, cytoplasm, nucleus, retinol-binding, transport, vitamin a, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P29373
Total number of polymer chains2
Total molecular weight31396.12
Authors
Jia, X.,Geiger, J.H. (deposition date: 2008-11-15, release date: 2009-10-27, Last modification date: 2011-07-13)
Primary citation
Jia, X.,Lee, K.S.,Vasileiou, C.,Borhan, B.,Geiger, J.H.
Two distinctive orientations of binding determined by a single mutation in the CRABPII mutant-C15-aldehyde complexes
To be Published,
Experimental method
X-RAY DIFFRACTION (1.54 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2231402.0%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution