3F97

Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by soman

Summary for 3F97

Entry DOI	10.2210/pdb3f97/pdb
Related	3D59 3D5E 3F96 3F98 3F9C
Descriptor	Platelet-activating factor acetylhydrolase, (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, SULFATE ION, ... (5 entities in total)
Functional Keywords	plasma platelet-activating factor acetylhydrolase, secreted protein, alpha/beta-hydrolase-fold, ldl-bound; lipoprotein associated phospholipase a2, lp-pla2, group viia pla2, glycoprotein, hydrolase, lipid degradation, polymorphism, soman, disease mutation, secreted
Biological source	Homo sapiens (Human)
Cellular location	Secreted, extracellular space: Q13093
Total number of polymer chains	2
Total formula weight	87590.29
Authors	Samanta, U.,Bahnson, B.J. (deposition date: 2008-11-13, release date: 2009-06-23, Last modification date: 2023-09-06)
Primary citation	Samanta, U.,Kirby, S.D.,Srinivasan, P.,Cerasoli, D.M.,Bahnson, B.J. Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochem Pharmacol, 78:420-429, 2009 Cited by PubMed: 19394314 DOI: 10.1016/j.bcp.2009.04.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation