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3F97

Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by soman

Functional Information from GO Data
ChainGOidnamespacecontents
A0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0009395biological_processphospholipid catabolic process
A0016486biological_processpeptide hormone processing
A0016787molecular_functionhydrolase activity
A0016788molecular_functionhydrolase activity, acting on ester bonds
A0034362cellular_componentlow-density lipoprotein particle
A0034364cellular_componenthigh-density lipoprotein particle
A0034374biological_processlow-density lipoprotein particle remodeling
A0034440biological_processlipid oxidation
A0034441biological_processplasma lipoprotein particle oxidation
A0034638biological_processphosphatidylcholine catabolic process
A0046469biological_processplatelet activating factor metabolic process
A0047499molecular_functioncalcium-independent phospholipase A2 activity
A0050729biological_processpositive regulation of inflammatory response
A0062234biological_processplatelet activating factor catabolic process
A0090026biological_processpositive regulation of monocyte chemotaxis
B0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0009395biological_processphospholipid catabolic process
B0016486biological_processpeptide hormone processing
B0016787molecular_functionhydrolase activity
B0016788molecular_functionhydrolase activity, acting on ester bonds
B0034362cellular_componentlow-density lipoprotein particle
B0034364cellular_componenthigh-density lipoprotein particle
B0034374biological_processlow-density lipoprotein particle remodeling
B0034440biological_processlipid oxidation
B0034441biological_processplasma lipoprotein particle oxidation
B0034638biological_processphosphatidylcholine catabolic process
B0046469biological_processplatelet activating factor metabolic process
B0047499molecular_functioncalcium-independent phospholipase A2 activity
B0050729biological_processpositive regulation of inflammatory response
B0062234biological_processplatelet activating factor catabolic process
B0090026biological_processpositive regulation of monocyte chemotaxis
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GD7 A 473
ChainResidue
AGLY152
ALEU153
ATYR160
AHIS272
ASER273
APHE274
ATRP298
AHIS351
AGLN352

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GD7 B 473
ChainResidue
BGLY152
BLEU153
BTYR160
BHIS272
BSER273
BPHE274
BTRP298
BPHE322
BHIS351
BGLN352

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 10
ChainResidue
ASER64
AASN90
BASN100
BLYS101
BHOH540

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 20
ChainResidue
BTYR321
BPHE322
BVAL350
BHIS351
BHOH453

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT B 21
ChainResidue
BTRP298
BPHE300
BTYR324
BHOH500

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 22
ChainResidue
ALYS201
AHOH534
BARG207
BHOH535
BHOH561

Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. IAVIGHSFGG
ChainResidueDetails
AILE267-GLY276

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:18784071
ChainResidueDetails
ASER273
BSER273

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037, ECO:0000269|PubMed:18784071
ChainResidueDetails
AASP296
AHIS351
BASP296
BHIS351

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN423
BASN423

221051

PDB entries from 2024-06-12

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