3F8Y
Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
Summary for 3F8Y
Entry DOI | 10.2210/pdb3f8y/pdb |
Related | 1U72 3F8Z 3F91 |
Descriptor | Dihydrofolate reductase, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | active site mutants ligand complex dhfr, nadp, one-carbon metabolism, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 1 |
Total formula weight | 22765.70 |
Authors | Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. (deposition date: 2008-11-13, release date: 2009-08-18, Last modification date: 2023-09-06) |
Primary citation | Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes. Biochemistry, 48:1702-1711, 2009 Cited by PubMed: 19196009DOI: 10.1021/bi801960h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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