3F8Y

Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Summary for 3F8Y

Entry DOI	10.2210/pdb3f8y/pdb
Related	1U72 3F8Z 3F91
Descriptor	Dihydrofolate reductase, 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	active site mutants ligand complex dhfr, nadp, one-carbon metabolism, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22765.70
Authors	Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. (deposition date: 2008-11-13, release date: 2009-08-18, Last modification date: 2023-09-06)
Primary citation	Cody, V.,Pace, J.,Makin, J.,Piraino, J.,Queener, S.F.,Rosowsky, A. Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes. Biochemistry, 48:1702-1711, 2009 Cited by PubMed: 19196009 DOI: 10.1021/bi801960h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation