3F7U

Crystal Structure of soluble domain of CA4 in complex with small molecule.

3F7U の概要

• エントリーDOI: 10.2210/pdb3f7u/pdb
• 関連するPDBエントリー: 3F7B 3FW3
• 分子名称: Carbonic anhydrase 4, ZINC ION, N-(3-methoxypropyl)-2-(phenylsulfanyl)-5-sulfamoylpyridine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: structure-based drug design. small molecule complex. co-crystal., cell membrane, disease mutation, glycoprotein, gpi-anchor, lipoprotein, lyase, membrane, metal-binding, retinitis pigmentosa, sensory transduction, vision, zinc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Lipid-anchor, GPI-anchor: P22748
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 123245.41

構造登録者

Pauly, T.A.,Ferre, R.A.A.,Greasley, S.E.,Paz, R. (登録日: 2008-11-10, 公開日: 2009-09-22, 最終更新日: 2024-04-03)

• 主引用文献: Vernier, W.,Chong, W.,Rewolinski, D.,Greasley, S.,Pauly, T.,Shaw, M.,Dinh, D.,Ferre, R.A.,Nukui, S.,Ornelas, M.,Reyner, E.; Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.; Bioorg.Med.Chem., 18:3307-3319, 2010; PubMed: 20363633; DOI: 10.1016/j.bmc.2010.03.014

実験手法

X-RAY DIFFRACTION (2 Å)