3F68

Thrombin Inhibition

3F68 の概要

• エントリーDOI: 10.2210/pdb3f68/pdb
• 関連するPDBエントリー: 1K22 2ZC9 2ZDA 2ZFP 2ZGX 3DUX
• 関連するBIRD辞書のPRD_ID: PRD_000611
• 分子名称: Prothrombin, Hirudin variant-2, N-acetyl-3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide, ... (6 entities in total)
• 機能のキーワード: blood clotting, hydrolase inhibitor, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35777.15

構造登録者

Baum, B.,Heine, A.,Klebe, G. (登録日: 2008-11-05, 公開日: 2009-10-20, 最終更新日: 2023-11-15)

• 主引用文献: Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G.; Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.; J.Mol.Biol., 391:552-564, 2009; PubMed: 19520086; DOI: 10.1016/j.jmb.2009.06.016

実験手法

X-RAY DIFFRACTION (1.75 Å)