3F66
Human c-Met Kinase in complex with quinoxaline inhibitor
Summary for 3F66
Entry DOI | 10.2210/pdb3f66/pdb |
Descriptor | Hepatocyte growth factor receptor, 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, ... (5 entities in total) |
Functional Keywords | c-met, protein kinase, quinoxaline, alternative splicing; atp-binding; chromosomal rearrangement; disease mutation; glycoprotein; kinase; membrane; nucleotide-binding; phosphoprotein; polymorphism; proto-oncogene; receptor; repeat; signal; transferase; transmembrane; tyrosine-protein kinase., transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 2 |
Total formula weight | 68920.69 |
Authors | |
Primary citation | Porter, J.,Lumb, S.,Lecomte, F.,Reuberson, J.,Foley, A.,Calmiano, M.,le Riche, K.,Edwards, H.,Delgado, J.,Franklin, R.J.,Gascon-Simorte, J.M.,Maloney, A.,Meier, C.,Batchelor, M. Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg.Med.Chem.Lett., 19:397-400, 2009 Cited by PubMed: 19059779DOI: 10.1016/j.bmcl.2008.11.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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