3F66
Human c-Met Kinase in complex with quinoxaline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 298 | 33845.2 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | C, G (A, B) | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | non-polymer | 388.4 | 2 | Chemie (IHX) | |||
| 3 | D, E, F, H, I (A, B) | GAMMA-BUTYROLACTONE | non-polymer | 86.1 | 5 | Chemie (GBL) | |||
| 4 | J (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 453 | Chemie (HOH) |
Sequence modifications
A, B: 1052 - 1349 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Leu 1272 | Val 1272 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67690.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1230.2 | |
| All* | Total formula weight | 68920.7 |
