3F5X

CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site

3F5X の概要

• エントリーDOI: 10.2210/pdb3f5x/pdb
• 分子名称: Cell division protein kinase 2, Cyclin-A2, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: kinase, pkc, protein kinase, inhibitor, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, cyclin, nucleus, transferase-cell cycle complex, transferase/cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P20248
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127936.36

構造登録者

Kiefer, J.R.,Day, J.E.,Caspers, N.L.,Mathis, K.J.,Kretzmer, K.K.,Weinberg, R.A.,Reitz, B.A.,Stegeman, R.A.,Trujillo, J.I.,Huang, W.,Thorarensen, A.,Xing, L.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X. (登録日: 2008-11-04, 公開日: 2009-02-03, 最終更新日: 2023-12-27)

• 主引用文献: Trujillo, J.I.,Kiefer, J.R.,Huang, W.,Thorarensen, A.,Xing, L.,Caspers, N.L.,Day, J.E.,Mathis, K.J.,Kretzmer, K.K.,Reitz, B.A.,Weinberg, R.A.,Stegeman, R.A.,Wrightstone, A.,Christine, L.,Compton, R.,Li, X.; 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor.; Bioorg.Med.Chem.Lett., 19:908-911, 2009; PubMed: 19097791; DOI: 10.1016/j.bmcl.2008.11.105

実験手法

X-RAY DIFFRACTION (2.4 Å)