3F5P
Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
3F5P の概要
エントリーDOI | 10.2210/pdb3f5p/pdb |
関連するPDBエントリー | 2ZM3 |
分子名称 | Insulin-like growth factor 1 receptor, 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile (3 entities in total) |
機能のキーワード | igf-1r, protein-inhibitor complex, tyrosine kinase, atp-binding, cleavage on pair of basic residues, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 16 |
化学式量合計 | 574323.54 |
構造登録者 | Xu, W.,Miller, L.M.,Mayer, S.C.,Berger, D.M.,Boschelli, D.H.,Boschelli, F. (登録日: 2008-11-04, 公開日: 2008-12-30, 最終更新日: 2023-11-15) |
主引用文献 | Miller, L.M.,Mayer, S.C.,Berger, D.M.,Boschelli, D.H.,Boschelli, F.,Di, L.,Du, X.,Dutia, M.,Floyd, M.B.,Johnson, M.,Kenny, C.H.,Krishnamurthy, G.,Moy, F.,Petusky, S.,Tkach, D.,Torres, N.,Wu, B.,Xu, W. Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 19:62-66, 2009 Cited by PubMed: 19041240DOI: 10.1016/j.bmcl.2008.11.037 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
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