3F07

Crystal Structure Analysis of Human HDAC8 complexed with APHA in a new monoclinic crystal form

3F07 の概要

• エントリーDOI: 10.2210/pdb3f07/pdb
• 関連するPDBエントリー: 3EW8 3EZP 3EZT 3F06 3F0R
• 分子名称: Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, hdac, metalloenzyme, acetylation, arginase fold, hdac8, histone deacetylase 8, hydroxamate inhibitor, mutant, alternative splicing, chromatin regulator, nucleus, repressor, transcription, transcription regulation
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q9BY41
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 130589.67

構造登録者

Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (登録日: 2008-10-24, 公開日: 2008-12-30, 最終更新日: 2023-09-06)

• 主引用文献: Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W.; Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.; Biochemistry, 47:13554-13563, 2008; PubMed: 19053282; DOI: 10.1021/bi801610c

実験手法

X-RAY DIFFRACTION (3.3 Å)