3EY4
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
3EY4 の概要
エントリーDOI | 10.2210/pdb3ey4/pdb |
関連するPDBエントリー | 2RBE 3BYZ |
分子名称 | 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one (3 entities in total) |
機能のキーワード | endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, polymorphism, signal-anchor, steroid metabolism, transmembrane, alpha beta, 3-layer(aba) sandwich, rossmann fold, nad(p)-binding rossmann-like domain, inhibitor, drug design |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 126168.94 |
構造登録者 | |
主引用文献 | Christopher, F.,Bartberger, M.D.,Bercot, E.A.,Chen, M.,Cupples, R.,Emery, M.,Fretland, J.,Guram, A.,Hale, C.,Han, N.H.,Hickman, D.,Hungate, R.W.,Hayashi, M.,Komorowski, R.,Liu, Q.Y.,Matsumoto, G.,Jean, D.J.St.,Ursu, S.,Voniant, M.,Xu, G.F.,Ye, Q.P.,Yuan, C.,Zhang, J.D.,Zhang, X.P.,Tu, H.,Wang, M.H. Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model To be Published, 2008 |
実験手法 |
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