3HP1

Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP

Replaces:  3EXK

Summary for 3HP1

• Entry DOI: 10.2210/pdb3hp1/pdb
• Descriptor: Deoxycytidine kinase, ADENOSINE-5'-DIPHOSPHATE, L-deoxythymidine, ... (4 entities in total)
• Functional Keywords: dck, l-dt, dm-dck, dck structure function studies, nucleoside kinase, protein-na complex, dck drug designing, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 1
• Total formula weight: 33307.21

Authors

Hazra, S.,Lavie, A. (deposition date: 2009-06-03, release date: 2009-06-16, Last modification date: 2023-09-06)

• Primary citation: Hazra, S.,Sabini, E.,Ort, S.,Konrad, M.,Lavie, A.; Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase.; Biochemistry, 48:1256-1263, 2009; PubMed: 19159229; DOI: 10.1021/bi802062w

Experimental method

X-RAY DIFFRACTION (2.31 Å)