3HP1

Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP

Replaces:  3EXK

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Deoxycytidine kinase	polymer	280	32637.8	1	UniProt (P27707) Pfam (PF01712) In PDB	Homo sapiens (human)	dCK
2	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	A	L-deoxythymidine	non-polymer		242.2	1	Chemie (LLT)
4		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 1 - 260 (UniProt: P27707)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ser 9	Cys 9	conflict
Met 104	Arg 104	engineered mutation
Ala 133	Asp 133	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32637.8
Non-Polymers*	Number of molecules	2
	Total formula weight	669.4
All*	Total formula weight	33307.2

*Water molecules are not included.