3EXF
Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex
Summary for 3EXF
Entry DOI | 10.2210/pdb3exf/pdb |
Related | 3EXE 3EXG 3EXH 3EXI |
Descriptor | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | heterotetramer; thiamine diphosphate-dependent enzyme; disease mutation; glycolysis; leigh syndrome; mitochondrion; oxidoreductase; phosphoprotein; alternative splicing; polymorphism; pyruvate; thiamine pyrophosphate; transit peptide, oxidoreductase |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion matrix: P08559 P11177 |
Total number of polymer chains | 8 |
Total formula weight | 315930.20 |
Authors | Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.-C.,Machius, M.,Li, J.,Chuang, D.T. (deposition date: 2008-10-16, release date: 2008-11-25, Last modification date: 2023-12-27) |
Primary citation | Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.C.,Machius, M.,Li, J.,Chuang, D.T. Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure, 16:1849-1859, 2008 Cited by PubMed: 19081061DOI: 10.1016/j.str.2008.10.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.998 Å) |
Structure validation
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