3EXF

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

3EXF の概要

• エントリーDOI: 10.2210/pdb3exf/pdb
• 関連するPDBエントリー: 3EXE 3EXG 3EXH 3EXI
• 分子名称: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: heterotetramer; thiamine diphosphate-dependent enzyme; disease mutation; glycolysis; leigh syndrome; mitochondrion; oxidoreductase; phosphoprotein; alternative splicing; polymorphism; pyruvate; thiamine pyrophosphate; transit peptide, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion matrix: P08559 P11177
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 315930.20

構造登録者

Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.-C.,Machius, M.,Li, J.,Chuang, D.T. (登録日: 2008-10-16, 公開日: 2008-11-25, 最終更新日: 2023-12-27)

• 主引用文献: Kato, M.,Wynn, R.M.,Chuang, J.L.,Tso, S.C.,Machius, M.,Li, J.,Chuang, D.T.; Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.; Structure, 16:1849-1859, 2008; PubMed: 19081061; DOI: 10.1016/j.str.2008.10.010

実験手法

X-RAY DIFFRACTION (2.998 Å)