3EW3
the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor
Summary for 3EW3
Entry DOI | 10.2210/pdb3ew3/pdb |
Descriptor | Prolactin, Prolactin receptor (2 entities in total) |
Functional Keywords | complex, glycoprotein, hormone, lactation, secreted, alternative splicing, membrane, receptor, transmembrane, hormone-hormone receptor complex, hormone/hormone receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01236 Membrane; Single-pass type I membrane protein: P05710 |
Total number of polymer chains | 3 |
Total formula weight | 75680.19 |
Authors | Broutin, I.,Jomain, J.B.,England, P.,Goffin, V. (deposition date: 2008-10-14, release date: 2009-11-03, Last modification date: 2023-11-01) |
Primary citation | Broutin, I.,Jomain, J.B.,Tallet, E.,van Agthoven, J.,Raynal, B.,Hoos, S.,Kragelund, B.B.,Kelly, P.A.,Ducruix, A.,England, P.,Goffin, V. Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2. J.Biol.Chem., 285:8422-8433, 2010 Cited by PubMed: 20053995DOI: 10.1074/jbc.M109.089128 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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