3EW3

the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor

3EW3 の概要

• エントリーDOI: 10.2210/pdb3ew3/pdb
• 分子名称: Prolactin, Prolactin receptor (2 entities in total)
• 機能のキーワード: complex, glycoprotein, hormone, lactation, secreted, alternative splicing, membrane, receptor, transmembrane, hormone-hormone receptor complex, hormone/hormone receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01236; Membrane; Single-pass type I membrane protein: P05710
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75680.19

構造登録者

Broutin, I.,Jomain, J.B.,England, P.,Goffin, V. (登録日: 2008-10-14, 公開日: 2009-11-03, 最終更新日: 2023-11-01)

• 主引用文献: Broutin, I.,Jomain, J.B.,Tallet, E.,van Agthoven, J.,Raynal, B.,Hoos, S.,Kragelund, B.B.,Kelly, P.A.,Ducruix, A.,England, P.,Goffin, V.; Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.; J.Biol.Chem., 285:8422-8433, 2010; PubMed: 20053995; DOI: 10.1074/jbc.M109.089128

実験手法

X-RAY DIFFRACTION (3.8 Å)