3EVS

Crystal structure of the GDF-5:BMP receptor IB complex.

Summary for 3EVS

Entry DOI	10.2210/pdb3evs/pdb
Related	1REW 1WAQ 2H62 2K3G 2QJB
Descriptor	Growth/differentiation factor 5, Bone morphogenetic protein receptor type-1B (3 entities in total)
Functional Keywords	ligand-receptor complex, cystin-knot ligand; three-finger toxn fold (receptor), cleavage on pair of basic residues, cytokine, disease mutation, dwarfism, glycoprotein, growth factor, secreted, atp-binding, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, receptor, serine/threonine-protein kinase, transferase, transmembrane, cytokine-transferase receptor complex, cytokine/transferase receptor
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P43026 Membrane; Single-pass type I membrane protein: P36898
Total number of polymer chains	2
Total formula weight	26620.34
Authors	Kotzsch, A.,Mueller, T.D. (deposition date: 2008-10-13, release date: 2009-03-10, Last modification date: 2023-12-27)
Primary citation	Kotzsch, A.,Nickel, J.,Seher, A.,Sebald, W.,Muller, T.D. Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28:937-947, 2009 Cited by PubMed: 19229295 DOI: 10.1038/emboj.2009.37 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation