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3ET3

Structure of PPARgamma with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid

Summary for 3ET3
Entry DOI10.2210/pdb3et3/pdb
Related3ET0 3ET1 3ET2
DescriptorPeroxisome proliferator-activated receptor gamma, Steroid receptor coactivator 1, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, ... (4 entities in total)
Functional Keywordsppar, pparg, ppargamma, drug discovery, diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, proto-oncogene, transferase, ubl conjugation
Biological sourceHomo sapiens (human)
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Cellular locationNucleus: P37231
Nucleus (By similarity): Q15788
Total number of polymer chains2
Total formula weight35663.31
Authors
Zhang, K.Y.J.,Wang, W. (deposition date: 2008-10-06, release date: 2009-02-17, Last modification date: 2023-09-06)
Primary citationArtis, D.R.,Lin, J.J.,Zhang, C.,Wang, W.,Mehra, U.,Perreault, M.,Erbe, D.,Krupka, H.I.,England, B.P.,Arnold, J.,Plotnikov, A.N.,Marimuthu, A.,Nguyen, H.,Will, S.,Signaevsky, M.,Kral, J.,Cantwell, J.,Settachatgull, C.,Yan, D.S.,Fong, D.,Oh, A.,Shi, S.,Womack, P.,Powell, B.,Habets, G.,West, B.L.,Zhang, K.Y.,Milburn, M.V.,Vlasuk, G.P.,Hirth, K.P.,Nolop, K.,Bollag, G.,Ibrahim, P.N.,Tobin, J.F.
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Proc.Natl.Acad.Sci.USA, 106:262-267, 2009
Cited by
PubMed: 19116277
DOI: 10.1073/pnas.0811325106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

数据于2024-03-27公开中

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