3ET3

Structure of PPARgamma with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Peroxisome proliferator-activated receptor gamma	polymer	292	33299.6	1	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (human)	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2	P	Steroid receptor coactivator 1	polymer	16	1974.3	1	UniProt (Q15788) In PDB	Homo sapiens (human)	NCoA-1, Nuclear receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52
3	A	3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid	non-polymer		389.4	1	Chemie (ET1)
4		water	water		18.0	217	Chemie (HOH)

Sequence modifications

A: 207 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 186	-	expression tag
Gly 187	-	expression tag
Ser 188	-	expression tag
Ser 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
Ser 196	-	expression tag
Ser 197	-	expression tag
Gly 198	-	expression tag
Leu 199	-	expression tag
Val 200	-	expression tag
Pro 201	-	expression tag
Arg 202	-	expression tag
Gly 203	-	expression tag
Ser 204	-	expression tag
His 205	-	expression tag
Met 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35273.9
Non-Polymers*	Number of molecules	1
	Total formula weight	389.4
All*	Total formula weight	35663.3

*Water molecules are not included.