3ET3
Structure of PPARgamma with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid
3ET3 の概要
エントリーDOI | 10.2210/pdb3et3/pdb |
関連するPDBエントリー | 3ET0 3ET1 3ET2 |
分子名称 | Peroxisome proliferator-activated receptor gamma, Steroid receptor coactivator 1, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, ... (4 entities in total) |
機能のキーワード | ppar, pparg, ppargamma, drug discovery, diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, proto-oncogene, transferase, ubl conjugation |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Nucleus: P37231 Nucleus (By similarity): Q15788 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 35663.31 |
構造登録者 | |
主引用文献 | Artis, D.R.,Lin, J.J.,Zhang, C.,Wang, W.,Mehra, U.,Perreault, M.,Erbe, D.,Krupka, H.I.,England, B.P.,Arnold, J.,Plotnikov, A.N.,Marimuthu, A.,Nguyen, H.,Will, S.,Signaevsky, M.,Kral, J.,Cantwell, J.,Settachatgull, C.,Yan, D.S.,Fong, D.,Oh, A.,Shi, S.,Womack, P.,Powell, B.,Habets, G.,West, B.L.,Zhang, K.Y.,Milburn, M.V.,Vlasuk, G.P.,Hirth, K.P.,Nolop, K.,Bollag, G.,Ibrahim, P.N.,Tobin, J.F. Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent Proc.Natl.Acad.Sci.USA, 106:262-267, 2009 Cited by PubMed: 19116277DOI: 10.1073/pnas.0811325106 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.95 Å) |
構造検証レポート
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