3ET3

Structure of PPARgamma with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid

3ET3 の概要

• エントリーDOI: 10.2210/pdb3et3/pdb
• 関連するPDBエントリー: 3ET0 3ET1 3ET2
• 分子名称: Peroxisome proliferator-activated receptor gamma, Steroid receptor coactivator 1, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, ... (4 entities in total)
• 機能のキーワード: ppar, pparg, ppargamma, drug discovery, diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, proto-oncogene, transferase, ubl conjugation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35663.31

構造登録者

Zhang, K.Y.J.,Wang, W. (登録日: 2008-10-06, 公開日: 2009-02-17, 最終更新日: 2023-09-06)

• 主引用文献: Artis, D.R.,Lin, J.J.,Zhang, C.,Wang, W.,Mehra, U.,Perreault, M.,Erbe, D.,Krupka, H.I.,England, B.P.,Arnold, J.,Plotnikov, A.N.,Marimuthu, A.,Nguyen, H.,Will, S.,Signaevsky, M.,Kral, J.,Cantwell, J.,Settachatgull, C.,Yan, D.S.,Fong, D.,Oh, A.,Shi, S.,Womack, P.,Powell, B.,Habets, G.,West, B.L.,Zhang, K.Y.,Milburn, M.V.,Vlasuk, G.P.,Hirth, K.P.,Nolop, K.,Bollag, G.,Ibrahim, P.N.,Tobin, J.F.; Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent; Proc.Natl.Acad.Sci.USA, 106:262-267, 2009; PubMed: 19116277; DOI: 10.1073/pnas.0811325106

実験手法

X-RAY DIFFRACTION (1.95 Å)