3ESO
Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide
Summary for 3ESO
Entry DOI | 10.2210/pdb3eso/pdb |
Related | 3ESN 3ESP |
Descriptor | Transthyretin, 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide (3 entities in total) |
Functional Keywords | hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28434.55 |
Authors | Connelly, S.,Wilson, I.A. (deposition date: 2008-10-06, release date: 2009-04-07, Last modification date: 2023-12-27) |
Primary citation | Johnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52:1115-1125, 2009 Cited by PubMed: 19191553DOI: 10.1021/jm801347s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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