3ERC

Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase with three fragments of RNA and 3'-deoxy ATP

Summary for 3ERC

• Entry DOI: 10.2210/pdb3erc/pdb
• Related: 2GA9 3ER8 3ER9
• Descriptor: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, Poly(A) polymerase catalytic subunit, RNA/DNA chimera (5'-D(CP*)R(UP*UP*)D(CP*C)-3'), ... (9 entities in total)
• Functional Keywords: polyadenylate polymerase, translocation, single tranded rna poly(a) polymerase, rna protein complex, processivity, heterodimer, nucleotidyltransferase, poxvirus; methyltransferase, mrna capping, mrna processing, s-adenosyl-l-methionine, transcription, transferase, transferase/dna, rna complex, transferase-dna, rna
• Biological source: vaccinia virus WR; More
• Cellular location: Virion : P07617
• Total number of polymer chains: 8
• Total formula weight: 187567.71

Authors

Li, C.,Li, H.,Zhou, S.,Poulos, T.L.,Gershon, P.D. (deposition date: 2008-10-01, release date: 2009-06-16, Last modification date: 2023-09-06)

• Primary citation: Li, C.,Li, H.,Zhou, S.,Sun, E.,Yoshizawa, J.,Poulos, T.L.,Gershon, P.D.; Polymerase Translocation with Respect to Single-Stranded Nucleic Acid: Looping or Wrapping of Primer around a Poly(A) Polymerase; Structure, 17:680-689, 2009; PubMed: 19446524; DOI: 10.1016/j.str.2009.03.012

Experimental method

X-RAY DIFFRACTION (3.21 Å)