3EQ1

The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution

Summary for 3EQ1

• Entry DOI: 10.2210/pdb3eq1/pdb
• Descriptor: Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, SULFATE ION (3 entities in total)
• Functional Keywords: alpha and beta protein, alternative splicing, cytoplasm, disease mutation, heme biosynthesis, porphyrin biosynthesis, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm (Probable): P08397
• Total number of polymer chains: 2
• Total formula weight: 80221.16

Authors

Kolstoe, S.E.,Gill, R.,Mohammed, F.,Wood, S.P. (deposition date: 2008-09-30, release date: 2009-03-03, Last modification date: 2023-11-01)

• Primary citation: Gill, R.,Kolstoe, S.E.,Mohammed, F.,Al D-Bass, A.,Mosely, J.E.,Sarwar, M.,Cooper, J.B.,Wood, S.P.,Shoolingin-Jordan, P.M.; Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria; Biochem.J., 420:17-25, 2009; PubMed: 19207107; DOI: 10.1042/BJ20082077

Experimental method

X-RAY DIFFRACTION (2.8 Å)