3EQ1

The Crystal Structure of Human Porphobilinogen Deaminase at 2.8A resolution

3EQ1 の概要

• エントリーDOI: 10.2210/pdb3eq1/pdb
• 分子名称: Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, SULFATE ION (3 entities in total)
• 機能のキーワード: alpha and beta protein, alternative splicing, cytoplasm, disease mutation, heme biosynthesis, porphyrin biosynthesis, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm (Probable): P08397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80221.16

構造登録者

Kolstoe, S.E.,Gill, R.,Mohammed, F.,Wood, S.P. (登録日: 2008-09-30, 公開日: 2009-03-03, 最終更新日: 2023-11-01)

• 主引用文献: Gill, R.,Kolstoe, S.E.,Mohammed, F.,Al D-Bass, A.,Mosely, J.E.,Sarwar, M.,Cooper, J.B.,Wood, S.P.,Shoolingin-Jordan, P.M.; Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria; Biochem.J., 420:17-25, 2009; PubMed: 19207107; DOI: 10.1042/BJ20082077

実験手法

X-RAY DIFFRACTION (2.8 Å)