3EPX
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol
Summary for 3EPX
| Entry DOI | 10.2210/pdb3epx/pdb |
| Related | 1HOZ 1HP0 1KIC 2FF2 3B9G 3EPW |
| Descriptor | IAG-nucleoside hydrolase, CALCIUM ION, (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidine-3,4-diol, ... (5 entities in total) |
| Functional Keywords | rossmann fold, active site loops, aromatic stacking, hydrolase |
| Biological source | Trypanosoma vivax |
| Total number of polymer chains | 2 |
| Total formula weight | 75964.61 |
| Authors | Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. (deposition date: 2008-09-30, release date: 2009-03-24, Last modification date: 2023-09-06) |
| Primary citation | Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochim.Biophys.Acta, 1794:953-960, 2009 Cited by PubMed: 19281874DOI: 10.1016/j.bbapap.2009.02.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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