3EOU

tRNA-guanine transglycosylase in complex with 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

3EOU の概要

• エントリーDOI: 10.2210/pdb3eou/pdb
• 関連するPDBエントリー: 3C2N 3EOS
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-4-(2-hydroxyethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• 機能のキーワード: tim barrel, glycosyltransferase, metal-binding, queuosine biosynthesis, transferase, trna processing
• 由来する生物種: Zymomonas mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43449.58

構造登録者

Ritschel, T.,Heine, A.,Klebe, G. (登録日: 2008-09-29, 公開日: 2009-09-15, 最終更新日: 2024-03-20)

• 主引用文献: Ritschel, T.,Kohler, P.C.,Neudert, G.,Heine, A.,Diederich, F.,Klebe, G.; How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase; Chemmedchem, 4:2012-2023, 2009; PubMed: 19894214; DOI: 10.1002/cmdc.200900343

実験手法

X-RAY DIFFRACTION (1.93 Å)