3EOG

Co-crystallization showing exon recognition by a group II intron

Summary for 3EOG

• Entry DOI: 10.2210/pdb3eog/pdb
• Related: 3EOH
• Descriptor: Group IIC intron, 5'-R(*UP*UP*AP*UP*UP*A)-3', MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: rna, ribonucleic acid, intron, group ii, exon
• Total number of polymer chains: 2
• Total formula weight: 136673.81

Authors

Toor, N.,Rajashankar, K.,Keating, K.S.,Pyle, A.M. (deposition date: 2008-09-26, release date: 2008-10-28, Last modification date: 2024-02-21)

Primary citation

Toor, N.,Rajashankar, K.,Keating, K.S.,Pyle, A.M.
Structural basis for exon recognition by a group II intron.
Nat.Struct.Mol.Biol., 15:1221-1222, 2008

PubMed Abstract: Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.

PubMed: 18953333
DOI: 10.1038/nsmb.1509

Experimental method

X-RAY DIFFRACTION (3.391 Å)