3EO3

Crystal structure of the N-acetylmannosamine kinase domain of human GNE protein

Summary for 3EO3

Entry DOI	10.2210/pdb3eo3/pdb
Descriptor	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, ZINC ION, UNKNOWN ATOM OR ION (3 entities in total)
Functional Keywords	non-protein kinase, sialic acid biosynthesis, structural genomics consortium, sgc, allosteric enzyme, atp-binding, disease mutation, isomerase, kinase, multifunctional enzyme, nucleotide-binding, phosphoprotein, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9Y223
Total number of polymer chains	3
Total formula weight	107251.04
Authors	Nedyalkova, L.,Tong, Y.,Rabeh, W.M.,Hong, B.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2008-09-26, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Tong, Y.,Tempel, W.,Nedyalkova, L.,Mackenzie, F.,Park, H.W. Crystal structure of the N-acetylmannosamine kinase domain of GNE. Plos One, 4:e7165-e7165, 2009 Cited by PubMed: 19841673 DOI: 10.1371/journal.pone.0007165 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.84 Å)

Structure validation