3EO3

Crystal structure of the N-acetylmannosamine kinase domain of human GNE protein

3EO3 の概要

• エントリーDOI: 10.2210/pdb3eo3/pdb
• 分子名称: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, ZINC ION, UNKNOWN ATOM OR ION (3 entities in total)
• 機能のキーワード: non-protein kinase, sialic acid biosynthesis, structural genomics consortium, sgc, allosteric enzyme, atp-binding, disease mutation, isomerase, kinase, multifunctional enzyme, nucleotide-binding, phosphoprotein, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9Y223
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107251.04

構造登録者

Nedyalkova, L.,Tong, Y.,Rabeh, W.M.,Hong, B.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (登録日: 2008-09-26, 公開日: 2008-10-07, 最終更新日: 2024-02-21)

• 主引用文献: Tong, Y.,Tempel, W.,Nedyalkova, L.,Mackenzie, F.,Park, H.W.; Crystal structure of the N-acetylmannosamine kinase domain of GNE.; Plos One, 4:e7165-e7165, 2009; PubMed: 19841673; DOI: 10.1371/journal.pone.0007165

実験手法

X-RAY DIFFRACTION (2.84 Å)