3EN5

Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor

Summary for 3EN5

Entry DOI	10.2210/pdb3en5/pdb
Related	3EN4 3EN6 3EN7
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywords	src, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, tyrosine-protein kinase
Biological source	Gallus gallus (bantam,chickens)
Cellular location	Cell membrane : P00523
Total number of polymer chains	2
Total formula weight	66104.02
Authors	Blair, J.A.,Apsel, B.,Knight, Z.A.,Shokat, K.M. (deposition date: 2008-09-25, release date: 2008-10-14, Last modification date: 2024-02-21)
Primary citation	Apsel, B.,Blair, J.A.,Gonzalez, B.,Nazif, T.M.,Feldman, M.E.,Aizenstein, B.,Hoffman, R.,Williams, R.L.,Shokat, K.M.,Knight, Z.A. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol., 4:691-699, 2008 Cited by PubMed: 18849971 DOI: 10.1038/nchembio.117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.66 Å)

Structure validation