3EML

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

Summary for 3EML

• Entry DOI: 10.2210/pdb3eml/pdb
• Descriptor: Human Adenosine A2A receptor/T4 lysozyme chimera, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, STEARIC ACID, ... (5 entities in total)
• Functional Keywords: adenosine, caffeine, gpcr, membrane protein, receptor, lcp, mesophase, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 1
• Total formula weight: 57171.93

Authors

Jaakola, V.-P.,Griffith, M.T.,Hanson, M.A.,Cherezov, V.,Chien, E.Y.T.,Lane, J.R.,Ijzerman, A.P.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (deposition date: 2008-09-24, release date: 2008-10-14, Last modification date: 2023-09-06)

• Primary citation: Jaakola, V.P.,Griffith, M.T.,Hanson, M.A.,Cherezov, V.,Chien, E.Y.,Lane, J.R.,Ijzerman, A.P.,Stevens, R.C.; The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.; Science, 322:1211-1217, 2008; PubMed: 18832607; DOI: 10.1126/science.1164772

Experimental method

X-RAY DIFFRACTION (2.6 Å)