3EMG

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

Summary for 3EMG

Entry DOI	10.2210/pdb3emg/pdb
Descriptor	Tyrosine-protein kinase SYK, 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywords	kinase, syk, alternative splicing, atp-binding, host-virus interaction, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	34106.22
Authors	Ter Haar, E. (deposition date: 2008-09-24, release date: 2008-12-02, Last modification date: 2024-04-03)
Primary citation	Farmer, L.J.,Bemis, G.,Britt, S.D.,Cochran, J.,Connors, M.,Harrington, E.M.,Hoock, T.,Markland, W.,Nanthakumar, S.,Taslimi, P.,Ter Haar, E.,Wang, J.,Zhaveri, D.,Salituro, F.G. Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK). Bioorg.Med.Chem.Lett., 18:6231-6235, 2008 Cited by PubMed Abstract: A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and potent inhibition in mast cell degranulation assays. PubMed: 18938080 DOI: 10.1016/j.bmcl.2008.09.106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation