3EM6

Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir

Summary for 3EM6

• Entry DOI: 10.2210/pdb3em6/pdb
• Related: 3EM3 3EM4
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: protease inhibitor, hyper susceptibility, drug resistance, hiv, darunavir, aids, hydrolase, protease
• Biological source: HIV-1 M:B_ARV2/SF2 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22859.28

Authors

Royer, C.J.,King, N.M.,Prabu-Jeyabalan, M.,Ng, C.,Nalivaika, E.A.,Schiffer, C.A. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2024-03-13)

• Primary citation: Prabu-Jeyabalan, M.,Ng, C.,King, N.M.,Bandaranayake, R.,Nalivaika, E.A.,Schiffer, C.A.; Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)