3EL8
Crystal structure of c-Src in complex with pyrazolopyrimidine 5
Summary for 3EL8
Entry DOI | 10.2210/pdb3el8/pdb |
Related | 3EL7 |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | c-src, kinase, pyrazolopyrimidine 5, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Gallus gallus (chicken) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 65908.73 |
Authors | Dar, A.C.,Lopez, M.S.,Shokat, K.M. (deposition date: 2008-09-20, release date: 2008-10-28, Last modification date: 2023-08-30) |
Primary citation | Dar, A.C.,Lopez, M.S.,Shokat, K.M. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem.Biol., 15:1015-1022, 2008 Cited by PubMed: 18940662DOI: 10.1016/j.chembiol.2008.09.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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