3EL8
Crystal structure of c-Src in complex with pyrazolopyrimidine 5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 2 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (chicken) | p60-Src, c-Src, pp60c-src |
2 | A | 1-{4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | non-polymer | 455.4 | 1 | Chemie (PD5) | |||
3 | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65453.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 455.4 | |
All* | Total formula weight | 65908.7 |