3EL0
Crystal structure of the inhibitor Nelfinavir (NFV) in complex with a multi-drug resistant HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) (Refer: FLAP+ in citation)
Summary for 3EL0
Entry DOI | 10.2210/pdb3el0/pdb |
Related | 3EKP 3EKQ 3EKT 3EKV 3EKW 3EKX 3EKY 3EL1 3EL4 3EL5 |
Descriptor | Protease, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | hiv-1, protease, multi-drug resistance, nelfinavir, aids, hydrolase |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22684.52 |
Authors | Prabu-Jeyabalan, M.,King, N.M. (deposition date: 2008-09-19, release date: 2009-09-01, Last modification date: 2024-02-21) |
Primary citation | King, N.M.,Prabu-Jeyabalan, M.,Bandaranayake, R.M.,Nalam, M.N.,Nalivaika, E.A.,Ozen, A.,Yilmaz, N.K.,Schiffer, C.A. Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease. Acs Chem.Biol., 7:1536-1546, 2012 Cited by PubMed: 22712830DOI: 10.1021/cb300191k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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