3EKR
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Summary for 3EKR
Entry DOI | 10.2210/pdb3ekr/pdb |
Related | 3EKO |
Descriptor | Heat shock protein HSP 90-alpha, 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | hsp90 inhibitors, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response |
Biological source | Homo sapiens |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 2 |
Total formula weight | 51855.37 |
Authors | Gajiwala, K.S. (deposition date: 2008-09-19, release date: 2008-11-25, Last modification date: 2023-08-30) |
Primary citation | Kung, P.P.,Funk, L.,Meng, J.,Collins, M.,Zhou, J.Z.,Johnson, M.C.,Ekker, A.,Wang, J.,Mehta, P.,Yin, M.J.,Rodgers, C.,Davies, J.F.,Bayman, E.,Smeal, T.,Maegley, K.A.,Gehring, M.R. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 18:6273-6278, 2008 Cited by PubMed: 18929486DOI: 10.1016/j.bmcl.2008.09.081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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