3EJ1

CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor

Summary for 3EJ1

• Entry DOI: 10.2210/pdb3ej1/pdb
• Related: 3EID
• Descriptor: Cell division protein kinase 2, Cyclin-A2, N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine (3 entities in total)
• Functional Keywords: cdk, cyclin, kinase, atp-binding, cell cycle, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 128192.55

Authors

Stevens, K.,Reno, M.,Alberti, J.,Price, D.,Kane-Carson, L.,Knick, V.,Shewchuk, L.,Hassell, A.,Veal, J.,Peel, M. (deposition date: 2008-09-17, release date: 2008-10-21, Last modification date: 2023-08-30)

• Primary citation: Stevens, K.L.,Reno, M.J.,Alberti, J.B.,Price, D.J.,Kane-Carson, L.S.,Knick, V.B.,Shewchuk, L.M.,Hassell, A.M.,Veal, J.M.,Davis, S.T.,Griffin, R.J.,Peel, M.R.; Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.; Bioorg.Med.Chem.Lett., 18:5758-5762, 2008; PubMed: 18835709; DOI: 10.1016/j.bmcl.2008.09.069

Experimental method

X-RAY DIFFRACTION (3.22 Å)