3EIZ

Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei, H32 crystal form

Summary for 3EIZ

• Entry DOI: 10.2210/pdb3eiz/pdb
• Related: 3EIY 3EJ0 3EJ2 3d63
• Descriptor: Inorganic pyrophosphatase (2 entities in total)
• Functional Keywords: structural genomics, ssgcid, bupsa.00023.a, pyrophosphatase, hydrolase, seattle structural genomics center for infectious disease
• Biological source: Burkholderia pseudomallei 1710b
• Cellular location: Cytoplasm (By similarity): Q3JUV5
• Total number of polymer chains: 1
• Total formula weight: 21473.63

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2008-09-17, release date: 2008-09-30, Last modification date: 2024-02-21)

Primary citation

Baugh, L.,Gallagher, L.A.,Patrapuvich, R.,Clifton, M.C.,Gardberg, A.S.,Edwards, T.E.,Armour, B.,Begley, D.W.,Dieterich, S.H.,Dranow, D.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Staker, B.L.,Phan, I.,Gillespie, A.,Choi, R.,Nakazawa-Hewitt, S.,Nguyen, M.T.,Napuli, A.,Barrett, L.,Buchko, G.W.,Stacy, R.,Myler, P.J.,Stewart, L.J.,Manoil, C.,Van Voorhis, W.C.
Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8:e53851-e53851, 2013

PubMed Abstract: The genus Burkholderia includes pathogenic gram-negative bacteria that cause melioidosis, glanders, and pulmonary infections of patients with cancer and cystic fibrosis. Drug resistance has made development of new antimicrobials critical. Many approaches to discovering new antimicrobials, such as structure-based drug design and whole cell phenotypic screens followed by lead refinement, require high-resolution structures of proteins essential to the parasite.

PubMed: 23382856
DOI: 10.1371/journal.pone.0053851

Experimental method

X-RAY DIFFRACTION (1.88 Å)